1973: Chromosome Structure and Function, Vol. XXXVIII
Organizer: James Watson
Symposium Participants v Foreword xvPHYSICAL ORGANIZATION OF DNA IN CHROMOSOMES On the Nature of Chromosome-sized DNA Molecules R. Kavenoff, L. C. Klotz, and B. H. Zimm 1Yeast Chromosomal DNA: Size, Structure, and Replication T. D. Petes, C. S. Newlon, B. Byers, and W. L. Fangman 9Studies on Nuclear and Mitochondrial DNA of Saceharomyces cerevisiae D. R. Cryer, C. D. Goldthwaite, S. Zinker, K.-B. Lam, E. Storm, R. Hirschberg, J. Blamire, D. B. Finkeistein, and J. Marmur 17RNA Molecules Bound to the Folded Bacterial Genome Stabilize DNA Folds and Segregate Domains of Supercoiling D. E. Pettijohn and R.. Hecht 31Studies on the Folded Chromosome of Escherichia coli A. Worcel, E. Burgi, J. Robinton, and C. L. Carison 43Electron Microscopic Studies on the Folded Chromosome of Escherichia coli H. Delius and A. Worcel 53Chromosomal Analogues: Long-range Order in Y-Condensed DNA L. S. Lerman 59X-Ray Diffraction Studies on Oriented Nucleohistone Gels J. F. Pardon, B. M. Richards, and R. I. Cotter 75Recent DNA Fiber Diffraction Studies and Their Implications for DNA Recognition S. Bram 83Quantitative Constraints in the Arrangement of Human DNA E. J. DuPraw 87ORGANIZATION OF CHROMOSOMES WITHIN THE NUCLEUSQuantitative Electron Microscopy of Chromosome Organization at Meiotic Prophase P. B. Moens 99Modified Synaptinemal Complexes in Spermatocytes of Stethophyma grossum G. H. Jones 109The Synaptinemal Complex in Homologous and Nonhomologous Pairing of Chromosomes C. B. Gullies, S. W. Rasmussen, and D. von Wettstein 117Duplication of Spindle Plaques and Integration of the Yeast Cell Cycle B. Byers and L. Goetsch 123On the Nature of Heteroploidy P. M. Kraemer, L. L. Deaven, H. A. Crissman, J. A. Steinkamp, and D. F. Petersen 133Some Aspects of Chromosome Structure in Eukaryotes D. E. Comings and T. A. Okada 145Conservation of Ar1cient Linkage Groups in Evolution and Some Insight into the Genetic Regulatory Mechanism of X-inactivation S. Ohno 155Laser Microirradiation of Chromosomes M. W. Bern 165Nuclear DNA Variation Due to B Chromosomes H. Rees and J. Hutchinson 175The Integration of Supernumerary Chromosomes into the Orthopteran Genome G. M. Hewitt 183DNA REPLICATIONDNA Replication in the Chromosomes of Eukaryotes H. G. Callan 195The Units of DNA Replication in Drosophila melanogaster Chromosomes A. B. Blumenthal, H. J. Kriegstein, and D. S. Hogness 205Functional Subunits of Chromosomal DNA from Higher Eukaryotes J. H. Taylor, M. Wu, and L. C. Erickson 225Discontinuous DNA Synthesis in Mammalian Cells J. A. Huberman and H. Horwitz 233The Temporal Order of Replication of Some DNA Cistrons I. Balazs, E. H. Brown, and C. L. Schildkraut 239The Assembly of Newly Replicated DNA into Chromatin H. Weintraub 247The Mechanism of SV40 DNA Replication N. P. Salzman, G. C. Fareed, E. D. Sebring, and M. M. Thoren 257Replication of Mitochondrial DNA: Replicative Forms of Molecules from Rat Tissues and Evidence for Discontinuous Replication D. R. Wolstenholme, K. Koike, and P. Cochran-Foists 267The Replication and Structure of Mitochondrial DNA in Animal Cells H. Kasamatsu, L. I. Grossman, D. L. Robberson, R. Watson, and J. Vinograd 281Relationships Among RNA-directed DNA Polymerase Activities of Avian Viruses and Chicken Cells S. Mizutani, C- Y. Kang, and H. M. Temin 289REPEATED SEQUENCES AND THEIR ARRANGEMENT INCHROMOSOMESArrangement and Characterization of Repetitive Sequence Elements in Animal DNAs E. H. Davidson, D. E. Graham, B. R. Neufeld, M. E. Chamberlin, C. S. Amenson, B. R. Hough, and R. J. Britten 295Functional Organization of the Mammalian Genome J. Bonner, W. T. Garrard, J. Gottesfeld, D. S. Holmes, J. S. Sevall, and M. Wilkes 303Oragnization and Transcription of DNA in Chromosomes and Mitochondria of Drosophila C. D. Laird, W. Y. Chooi, E. H. Cohen, E. Dickson, N. Hutchinson, and S. H. Turner 311Characterization of the Rapidly Renaturing Sequences in the Main CsCl Density Bands of Drosophila, Mouse, and Human DNA J. E. Hearst, T. R. Cech, K. A. Marx, A. Rosenfeld, and J. R. Allen 329Bulk Isolation of Metaphase Chromosomes from an In Vitro Cell Line of Drosophila melanogaster C. V. Hanson and J. E. Hearst 341The Rolling Helix: A Model for the Eukaryotic Gene? C. A. Thomas, Jr 347Cyclodromes and Palindromes in Chromosomes C. A. Thomas, Jr., R. E. Pyeritz, D. A. Wilson, B. M. Dancis, C. S. Lee, M. D. Bick, H. L. Huang, and B. H. Zimin 353Repetitive Sequences in Isolated Thomas Circles from Drosophila melanogaster F. H. Schachat and D. S. Hogness 371Cleavage of Mouse DNA by a Restriction Enzyme as a Clue to the Arrangement of Genes M. Botchan, G. McKenna, and P. A. Sharp 383 Appendix: Cleavage of Integrated SV40 RI Restriction Endonuclease M. Botchan and G. McKennaRepetitive DNA in Polytene Chromosomes of Drosophila melanogaster G. T. Rudkin and K. D. Tartof 397The Organization of Highly Repeated DNA Sequences in Drosophila melano- gaster Chromosomes W. J. Peacock, D. Brutlag, E. Goldring, R. Appels, C. W. Hinton, and D. L. Lindsley 405The Satellite DNAs of Drosophila virilis J. G. Gall, E. H. Cohen, and D. D. Atherton 417The Evolution of Satellite DNA in Drosophila virilis M. Blumenfeld 423The Action of a Restriction Endonuclease on Higher Organism DNA E. M. Southern and G. Roizes 429Acridine Orange and the Investigation of Chromosome Banding M. Bobrow 435Fluorescent Probes of Chromosomal DNA Structure: Three Classes of Acridines B. Weisblum 441THE GENES FOR RIBOSOMAL AND TRANSFER RNA Clustered Arrangement of tRNA Genes of Xenopus laevis S. G. Clarkson and M. L. Birnstiel 451Studies on the Transfer RNA Genes of Drosophila T. A. Grigliatti, B. N. White, G. M. Tener, T. C. Kaufman, J. J. Holden, and D. T. Suzuki 461Localization of Repeated DNA Sequences in Xenopus Chromosomes M. L. Pardue 475On the Cell Stage of X-Y Recombination During rDNA Magnification in Dro- sophila F. Ritossa, F. Scalenghe, N. Di Turi, and A. M. Contini 483Unequal Mitotic Sister Chromatid Exchange and Disproportionate Replication as Mechanisms Regulating Ribosomal RNA Gene Redundancy K. D. Tartof 491The Structure and Evolution of Ribosomal and 5 S DNAs in Xenopus laevis and Xenopus mullen D. D. Brown and K. Sugimoto 501Unequal Crossover and the Evolution of Multigene Families G. P. Smith 507
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Gene Pool of Higher Organisms as a Product of Evolution M. Kimura 515 Secondary Structure Maps of Ribosomal RNA and Its Precursors as Determined by Electron Microscopy P. K. Wellauer and I. B. Dawid 525 The Nucleolus and the Rolling Circle D. Hourcade, D. Dressler, and J. Wolfson 537 The Synthesis of Amplified Ribosomal DNA G. P. Tocchini- Valentini, V. Mahdavi, R. Brown, and M. Crippa 551 The Molecular Organization of the Chromomeres of Acheta Involved in Ribo- somal DNA Amplification A. Lima-de-Faria 559 CHROMOMERES AND BANDS An Examination of the One Cistron:One Chromomere Concept B. H. Judd and M. W. Young 573 Analysis of a Whole Chromosome in Drosophila B. Hochrnan 581 The One Band-One Gene Hypothesis: Evidence from a Cytogenetic Analysis of Mutant and Nonmutant Rearrangement Breakpoints in Drosophila melano- gaster G. Lefevre, Jr 591 Organization of Chromomeres V. Sorsa 601 Chromosome Structure in Ciliated Protozoans D. M. Prescott and K. G. Munti 609 LOOPS, PUFFS, AND BALBIANI RINGS Chromosome Puffs and Gene Expression in Polytene Cells U. Grossbach 619 The Transcription Unit in Balbiani Ring 2 of Chironomus tentans B. Daneholt and H. Hosick 629 Repeated Nucleotide Sequences in a Single Puff of Chironomws tentans Polytene Chromosomes B. Lambert 637 Structure and Function in the Genome of Drosophila hydei H. D. Berendes, C. Abaso, P. J. Helmsing, H. J. Leenders, and J. Derksen 645 Temporal Control of Puffing Activity in Polytene Chromosomes M. Ash- burner, C. Chihara, P. Meltzer, and G. Richards 655 Local Structural Variations of the Y Chromosome of Drosophila hydei and Their Correlation to Genetic Activity O. Hess 663 Structure and Function of the Y Chromosome of Drosophila hydei W. Hennig, G. F. Meyer, I. Hennig, and O. Leoncini 673 Genetic Organization and Regulation of the Drosophila Y Chromosome T. G. Sanders and G. B. Ayles 685 Chromosome Products in Chironomus tentans Salivary Gland Cells J. E. Edström and R. Tanguay 693 STRUCTURAL GENES AND THEIR PRODUCTS The Length of Fibroin Structural Gene Sequences in Bombyx mori DNA P. M. Lizardi and D. D. Brown 701 DNA Sequences Neighboring the Duck Hemoglobin Genes J. O. Bishop and K. B. Freeman 707 Messenger RNAs for Individual Histone Proteins: Fingerprint Analysis and In Vitro Translation M. Grunstein, S. Levy, P. Schedl, and L. Kedes 717 Immunoglobulin Genes: Arranged in Tandem or in Parallel? O. Smithies 725 Immunoglobulin Genes: A Test of Somatic vs. Germ Line Hypothesis by RNA/ DNA Hybridization T. Delovitch and C. Baglioni 739 Regulated Expression of Mammalian Genes: Globin and Immunoglobulin as Model Systems P. Leder, J. Ross, J. Gielen, S. Packman, Y. ikawa, H. Aviv, and D. Swan 753 CHROMATIN Transcription and Chromatin Structure B. J. McCarthy, J. T. Nishiura, D. Doenecke, D. S. Nasser, and C. B. Johnson 763 Chromatin Template Activity and Chromatin Structure R. Axel, H. Cedar, and G. Felsenfeld 773 Phosphorylation of DNA-binding Nuclear Acidic Proteins and Gene Activation in the HeLa Cell Cycle V. G. Allfrey, A. Inoue, J. Karn, E. M. Johnson, and G. Vidali 785 Enzymatic Modifications and Their Possible Roles in Regulating the Binding of Basic Proteins to DNA and in Controlling Chromosomal Structure A. J. Louie, E. P. M. Candido, and G. H. Dixon 803 A Prologue to the Study of the Nonhistone Chromosomal Proteins S. C. R. Elgin, J. B. Boyd, L. E. Hood, W. Wray, and F. C. Wu 821 Biochemical and Morphological Studies of Partially Purified Chinese Hamster Chromosomes E. Stubblefteld and W. Wray 835 TRANSCRIPTION Sequences of Controlling Regions of the Lactose Operon W. Gilbert, N. Maizels, and A. Maxam 845 Control Elements in the DNA of Bacteriophagel T. Maniatis, M. Ptashne, and R. Maurer 857 On the Structural Organization of the Transcriptional Unit in Animal Chromo- somes G. P. Georgiev, A. J. Varshavsky, A. P. Ryskov, and R. B. Church 869 The Globin Gene: Structure and Expression J. Paul, R. S. Gilmour, N. Affara, G. Birnie, P. Harrison, A. Hell, S. Humphries, J. Windass, and B. Young 885 Origin of mRNA in HeLa Cells and the Implications for Chromosome Structure W. Jelinek, G. Molloy, M. Salditt, R. Wall, D. Sheiness, and J. E. Darnell, Jr 891 Transcription and Structure of the Genome of the Cellular Slime Mold Dictyos- telium discoideum H. F. Lodish, R. A. Firtel, and A. Jacobson 899 Ultrastructure of Active Eukaryotic Genomes B. A. Hamkalo, O. L. Miller, Jr., and A. H. Bakken 915 Some Properties of RNA: Protein Complexes from the Nucleus of Eukaryotic Cells T. Martin, P. Billings, A. Levey, S. Ozarslan, T. Quinlan, H. Swift, and L. Urbas 921 Sequence Arrangement in mRNA: Presence of Poly(A) and Identification of a Repetitive Fragment at the 5¢ End M. Crippa, I. Meza, and D. Dma 933 An Electron Microscope Study of Sindbis Virus RNA M-T. Hsu, H-J. Kung, and N. Davidson 943 Molecular Models and Combinatorial Principles in Cell Differentiation and Morphogenesis A. Gierer 951 SUMMARY Chromosomes 1973: Organization of Genetic Material in Eukaryotes-Progress and Prospects H. Swift 963
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